Positive inotropic effects of hydralazine in human subjects: comparison with prazosin in the setting of congestive heart failure.
Am J Cardiol
; 46(6): 1039-44, 1980 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-7446418
ABSTRACT
Hydralazine possesses positive inotropic properties in animal model preparations. To determine whether this vasodilator elicits a positive inotropic response in the failing human ventricle, hydralazine, 75 or 100 mg, was administered orally to 14 patients with left ventricular dysfunction and congestive heart failure; the results were compared with those of first-dose prazosin at 5 and 10 mg. The duration of the preejection period and the isovolumic developed pressure/duration of isovolumic contraction (delta P/delta t) were used as indexes of inotropy. Prazosin did not effect a significant response in the duration of the preejection period or in the delta P/delta t. Hydralazine significantly shortened the preejection period and increased the delta P/delta t over 8 hours after administration; these data suggest that hydralazine elicits a positive inotropic response in the failing human ventricle.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinazolinas
/
Prazosina
/
Insuficiência Cardíaca
/
Hidralazina
/
Contração Miocárdica
Limite:
Humans
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article