Stratification of the channel domain in neurotransmitter receptors.
Curr Opin Cell Biol
; 5(4): 688-93, 1993 Aug.
Article
em En
| MEDLINE
| ID: mdl-7504932
ABSTRACT
Analyses of the ionic pore of ligand-gated ion channels at the amino acid level reveal a structural and functional stratification of the M2 channel domain. Mutations in the equatorial and outer regions affect channel gating, whereas mutations of other amino acid rings alter ionic permeability or selectivity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estrutura Terciária de Proteína
/
Receptores de Neurotransmissores
/
Canais Iônicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article