GAP-43 persists in adulthood and coexists with SP and CGRP in human trigeminal sensory neurones.
Neuroreport
; 5(17): 2349-52, 1994 Nov 21.
Article
em En
| MEDLINE
| ID: mdl-7533558
ABSTRACT
Immunohistochemistry was used to examine the occurrence and colocalization of the growth-associated protein GAP-43 with substance P (SP) and calcitonin gene-related peptide (CGRP) in the human trigeminal ganglion and sensory nucleus at perinatal and adult life stages. The results obtained show that GAP-43-like immunoreactive (LI) material persists in trigeminal primary sensory neurones of the normal adult; the GAP-43-LI ganglionic population partially overlaps with those immunoreactive to SP and CGRP; the distribution pattern of the protein in the spinal nucleus varies with age; in the adult subnucleus caudalis GAP-43 is co-distributed with SP and CGRP. It is suggested that the trigeminal GAP-43-LI neuronal system may retain the capacity for structural and functional plasticity in adult life.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Núcleos do Trigêmeo
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Envelhecimento
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Glicoproteínas de Membrana
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Substância P
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Peptídeo Relacionado com Gene de Calcitonina
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Substâncias de Crescimento
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Proteínas do Tecido Nervoso
Limite:
Adult
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Aged
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Female
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Humans
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Infant
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Male
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Middle aged
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Newborn
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article