Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats.
Brain Res
; 679(1): 184-7, 1995 May 08.
Article
em En
| MEDLINE
| ID: mdl-7544223
ABSTRACT
We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Pilocarpina
/
Convulsões
/
Aminoácido Oxirredutases
/
Ácido Caínico
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article