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A study on lymphocyte activation in maedi-visna virus induced pneumonia.
Begara, I; Lujan, L; Hopkins, J; Collie, D D; Miller, H R; Watt, N J.
Afiliação
  • Begara I; Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, UK.
Vet Immunol Immunopathol ; 45(3-4): 197-210, 1995 Apr.
Article em En | MEDLINE | ID: mdl-7545850
The stage of activation of bronchoalveolar lavage fluid (BALF) lymphocytes and peripheral blood lymphocytes (PBL) from maedi-visna virus (MVV) infected (n = 7) and control (n = 7) sheep was investigated by assessing four parameters of lymphocyte activation; lymphocyte size and complexity, loss of CD5+ T cells, expression of cell surface interleukin-2 receptor (IL-2R) and expression of DR and DQ MHC Class II molecules. BALF lymphocytes from MVV-infected animals had a significant loss of CD5+ lymphocytes (P < 0.05) and upregulation of DR and DQ MHC Class II molecules compared with controls, consistent with BALF lymphocyte activation. No changes in cell size and complexity or expression of IL-2R were observed. No evidence of PBL activation was detected. These findings suggest an impaired BALF lymphocyte activation during MVV infection.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Linfócitos T / Vírus Visna-Maedi / Pneumonia Intersticial Progressiva dos Ovinos Limite: Animals Idioma: En Ano de publicação: 1995 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Linfócitos T / Vírus Visna-Maedi / Pneumonia Intersticial Progressiva dos Ovinos Limite: Animals Idioma: En Ano de publicação: 1995 Tipo de documento: Article