Transmission of thyrotoxicosis of autoimmune type by sibling allogeneic bone marrow transplant.
Eur J Endocrinol
; 133(5): 564-6, 1995 Nov.
Article
em En
| MEDLINE
| ID: mdl-7581986
ABSTRACT
This case report is on a 25-year-old male with acute myeloblastic leukaemia who achieved a remission after cytoxic therapy and whole-body irradiation. He received a bone marrow transplant from his human leucocyte antigen (HLA)-identical sister who had unsuspected autoimmune thyroid disease. Nine months later the bone marrow recipient developed thyrotoxicosis of autoimmune type at a time when his circulating lymphocytes were of 46XX karyotype. It is suspected that the thyrotoxicosis resulted from the transplantation of a clone of lymphocytes predisposed to the production of thyroid-stimulating autoantibodies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Tireotoxicose
/
Transplante de Medula Óssea
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article