DMSA chelation during co-exposure to lead: increased locomotor activity in lead-exposed mice but not controls.
Physiol Behav
; 57(5): 863-7, 1995 May.
Article
em En
| MEDLINE
| ID: mdl-7610136
ABSTRACT
We investigated the effect of chelating agent meso-2,3 dimercaptosuccinic acid (DMSA) on indices of "hyperactive" behavior in lead-exposed and control Binghamton Heterogeneous Stock (Het) mice. As expected, 6 weeks of ingestion of 0.5% lead acetate in drinking water reduced immobility in a forced water swim relative to controls. DMSA did not attenuate this behavioral change. In fact, DMSA interacted with lead exposure to increase locomotor activity in the forced water swim. DMSA also apparently excacerbated lead's tendency to reduce immobility. While any generalizations to human populations should be cautioned, these results and others suggest the need for further research.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Nível de Alerta
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Succímero
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Intoxicação por Chumbo
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Atividade Motora
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article