Non-contraceptive hormones and the risk of rheumatoid arthritis in menopausal women.
Int J Epidemiol
; 23(6): 1248-55, 1994 Dec.
Article
em En
| MEDLINE
| ID: mdl-7721528
ABSTRACT
BACKGROUND:
Several reproductive factors appear to affect a women's risk of developing rheumatoid arthritis. This study's purpose was to determine whether use of non-contraceptive hormones is among them.METHODS:
A population-based case-control study was conducted in King County, Washington and Group Health Cooperative of Puget Sound, a prepaid health plan. New cases of rheumatoid arthritis in peri- or postmenopausal women (n = 135) were verified through clinical examination and compared with 592 controls. Both groups were interviewed in person about hormone use and demographic and reproductive factors.RESULTS:
The age-adjusted relative risk (RR) among women who had ever used non-contraceptive oestrogens was 1.04 (95% confidence interval [CI] 0.70-1.55), and among women who had ever used progestins it was 0.66 (95% CI 0.40-1.08). For current users of oestrogen only, the RR was 0.97 (95% CI 0.62-1.53), and among current users of oestrogen plus progestin it was 0.81 (95% CI 0.45-1.45). Multivariate analyses yielded similar results. There was little evidence of a dose-response relationship with duration of use or with frequency of progestin use.CONCLUSIONS:
Use of non-contraceptive oestrogens appears to have little effect on the risk of developing rheumatoid arthritis in menopausal women. There may be a modest reduction in risk among progestin users.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Progestinas
/
Menopausa
/
Estrogênios
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article