[Resistance and resistances]. / Résistance et résistances.

ABSTRACT

Drug resistance is a frequent clinical event, induced by more than one mechanism. It is intrinsic and/or acquired by tumoral cell population. But the failure of chemotherapy is also associated to intratumoral drug incorporation and altered drug and/or cell metabolism. Prevention of drug resistance needs integration of pharmacokinetic, biochemical and pathological characteristics of tumoral cell population.