Does phosphorylase kinase control glycogen biosynthesis in skeletal muscle?
FEBS Lett
; 362(3): 271-5, 1995 Apr 10.
Article
em En
| MEDLINE
| ID: mdl-7729511
ABSTRACT
Immunoblotting as well as enzyme assays demonstrate the presence of the self-glucosylating protein, glycogenin, in the protein-glycogen complex, in the sarcoplasmic reticulum and in phosphorylase kinase. In all three compartments glycogenin occurs in different, albeit, defined glucosylated forms, which upon deglucosylation are converted into a 42 kDa form. We suggest that phosphorylase kinase might have a dual function in glycogen biogenesis firstly, control of glycogen degradation in the protein-glycogen complex via phosphorylation of glycogen phosphorylase b; secondly, regulation of glycogen biosynthesis on the sarcoplasmic reticular membranes via phosphorylation and thereby inhibition of glycogen synthase.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosforilase Quinase
/
Glicoproteínas
/
Músculo Esquelético
/
Glicogênio
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article