[Comparative study of cefixime versus amoxicillin-clavulanic acid combination in the oral treatment of urinary tract infections in children]. / Etude comparant le céfixime à l'association amoxicilline-acide clavulanique dans le traitement par voie orale des infections urinaires de l'enfant.
Arch Pediatr
; 2(2): 136-42, 1995 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-7735445
ABSTRACT
BACKGROUND:
Acute febrile infections suggestive of pyelonephritis require treatment by broad-spectrum antibiotics capable of reaching significant tissue levels. This study compares efficacy and safety of cefixime with amoxycillin + clavulanic acid in urinary tract infections. POPULATION ANDMETHODS:
Fifty seven children aged 5 months to 14 years treated for urinary tract infection in ten pediatric centres for a period of 10 months had been randomly included in the study. Thirty (22 girls and eight boys) were given cefixime and 27 (24 girls and three boys) amoxycillin-clavulanate. Efficacy was evaluated in only 36 patients whose bacteria were susceptible to both antibiotics (26 pyelonephritis and ten cystitis).RESULTS:
Sixteen patients out of the 19 given cefixime recovered vs. 14 out of the 17 given amoxycillin-clavulanate with no significant difference between both groups. Bacteria were more often susceptible to cefixime (100% of cases) than to amoxycillin-clavulanate (69%) (p < or = 0.0001). Safety was good and comparable in both groups.CONCLUSION:
Cefixime given per os seems effective and safe in treating urinary tract infections. These results have to be confirmed by further studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Urinárias
/
Cefotaxima
/
Ácidos Clavulânicos
/
Amoxicilina
/
Antibacterianos
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
Fr
Ano de publicação:
1995
Tipo de documento:
Article