A study of gender, strain and age differences in mouse liver glutathione-S-transferase.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
; 110(1): 35-40, 1995 Jan.
Article
em En
| MEDLINE
| ID: mdl-7749601
ABSTRACT
The hepatic cytosolic glutathione S-transferase (GST) activity in four strains of the mouse and one strain of the rat was studied with the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), ethachrynic acid (ETHA), cumene hydroperoxide (CU) and atrazine as the in vitro substrates. In the mouse, significant gender, strain and age-related differences in the GST activity towards CDNB and atrazine were found between adolescent and sexually mature males and females of the CD-1, C57BL/6, DBA/2 and Swiss-Webster strains, and the differences were larger with atrazine as the substrate. With DCNB and CU a similar tendency was observed, however not significant for all strains. The GST activity towards ETHA was also gender and strain specific, but revealed no age-related differences. The herbicide atrazine seems to be a useful substrate in the study of strain and age-related differences in the mouse GST class Pi.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Caracteres Sexuais
/
Glutationa Transferase
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article