Potential approaches for myocardial regeneration.
Ann N Y Acad Sci
; 752: 446-54, 1995 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-7755290
ABSTRACT
Cardiomyocytes in the adult mammal retain little or none of their developmental capacity for hyperplastic growth. As a consequence of this differentiated, nonproliferative phenotype, cardiomyocyte loss due to injury or disease is irreversible. Therapeutic intervention in end-stage diseased hearts is currently limited to cardiac transplantation. An increase in cardiomyocyte number in diseased hearts could improve function. Augmentation of the cardiomyocyte population may be achievable by the expression of regulatory proteins in the myocardium, or by intracardiac grafting of exogenous cardiomyocytes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Coração
/
Miocárdio
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article