beta-Amyloid(25-35) induces the production of interleukin-8 from human monocytes.
J Neuroimmunol
; 59(1-2): 29-33, 1995 Jun.
Article
em En
| MEDLINE
| ID: mdl-7797618
ABSTRACT
In an effort to unravel some of the cellular actions of beta-amyloid protein (A beta), we investigated its effects on interleukin-8 (IL-8) production from human monocytes. Supernatants harvested from cultured monocytes stimulated with the neurotoxic fragment 25-35 of beta-amyloid [A beta(25-35)] contained significant amounts of IL-8. Northern blot analysis demonstrated that A beta(25-35) also induced IL-8 mRNA accumulation. The effect of A beta(25-35) on IL-8 mRNA accumulation and secretion was not mimicked by a scrambled A beta(25-35) peptide, and was not affected by polymyxin B sulphate, which, on the other hand, almost completely abolished the effect of lipopolysaccharide. Our results uncover a new biological action of beta-amyloid that of stimulating the production of a chemokine from monocytes.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Monócitos
/
Peptídeos beta-Amiloides
/
Interleucina-8
Limite:
Humans
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article