Determination of a maximum number of artificial inseminations by donor children per sperm donor.
Fertil Steril
; 63(2): 419-21, 1995 Feb.
Article
em En
| MEDLINE
| ID: mdl-7843456
ABSTRACT
OBJECTIVE:
To determine a safe maximum number of artificial insemination (donor insemination [DI]) children per anonymous sperm donor.DESIGN:
Multiparameter calculation model of contribution of DI to inbreeding.SETTING:
Data of the collaborative DI centers and demographic population data of The Netherlands.INTERVENTIONS:
Calculations of the contribution of DI to inbreeding were made, taking into account all possible unintentional consanguineous matings and consanguineous inseminations with a coefficient of inbreeding (F) of > or = 1/16 for the offspring. MAIN OUTCOMEMEASURE:
Coefficient of inbreeding (F).RESULTS:
The contribution of DI to inbreeding was estimated to be 46.6 x 10(-6) + k (1.66 x 10(-6)) (k = number of DI children per donor). When only half-sibling matings were considered, the kmax was 32. When all possible consanguineous matings and inseminations were taken into account, kmax decreased with 28% to 25 children.CONCLUSION:
Calculations of a maximum number of DI children per sperm donor, based on possible enhancement of inbreeding and given the Dutch population and DI setting, show that 25 children per DI donor is a safe threshold for clinical practice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consanguinidade
Limite:
Female
/
Humans
/
Male
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article