A correlative approach for the identification of antimutagens that demonstrate chemopreventive activity.
Anticancer Res
; 14(5A): 1775-8, 1994.
Article
em En
| MEDLINE
| ID: mdl-7847810
ABSTRACT
Seventy natural and synthetic compounds were tested for potential to inhibit mutation induced by 7,12-dimethylbenz(a)anthracene (DMBA) in Salmonella typhimurium strain TM677. Results were compared with their ability to inhibit DMBA-induced preneoplastic lesions in a mouse mammary gland organ culture system. The response mediated by fifty-five of the test compounds was either positive or negative in both test systems, indicating that the combined use of these assays should aid in the discovery of antimutagenic agents that have cancer chemopreventive potential.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antimutagênicos
/
Anticarcinógenos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article