Late neurological, cognitive and behavioural sequelae of prenatal exposure to coumarins: a pilot study.
Early Hum Dev
; 38(2): 97-109, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-7851309
ABSTRACT
Neurological, cognitive and behavioural development were assessed in a group of 21, 8- to 10-year old children whose mothers took coumarins during pregnancy. Findings were compared with those in a group of 17 control children. The study was performed to test whether it is feasible to carry out a reliable retrospective study of late effects of prenatal exposure to coumarins. This turned out to be the case. In this small pilot study, no statistical significant differences were found between the study and control group, nevertheless a few findings were remarkable. One child showed severe neurological abnormalities, which may be due to prenatal exposure to oral anticoagulants. The children with the lowest scores on the neurological assessment and the lowest IQ-scores, were found in the exposed group. Obviously, the number of children in this study is too small to conclude if there has been definite effects from coumarin, but these results indicate that a large follow-up study is required. In the present paper, we have shown that such a study is feasible.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
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Transtornos do Comportamento Infantil
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Transtornos Cognitivos
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Cumarínicos
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Doenças do Sistema Nervoso
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
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Child
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article