Sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-HT1A receptor agonist, buspirone, after prolonged chronic administration.
Eur J Pharmacol
; 239(1-3): 69-73, 1993 Aug 03.
Article
em En
| MEDLINE
| ID: mdl-7901030
ABSTRACT
The effect of prolonged administration of high doses of buspirone on its 5-hydroxytryptamine (5-HT) release-inhibitory and anxiolytic-like properties was investigated. The 5-HT release-inhibitory effect of a challenge dose of buspirone (0.5 mg/kg, s.c.) was identical in rats chronically treated with vehicle or buspirone (10 mg/kg, b.i.d. for 10 weeks), as estimated by in vivo microdialysis in the ventral hippocampus. In the same set of animals there was a significant anxiolytic-like effect in the elevated plus-maze after 5 weeks of treatment with buspirone. The results indicate that the functional capacity of 5-HT release-controlling 5-HT1A autoreceptors is retained upon chronic administration of buspirone, and that this effect may well be associated with the anxiolytic-like action of the compound.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiolíticos
/
Comportamento Animal
/
Buspirona
/
Serotonina
/
Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article