The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation.
Cell
; 74(1): 15-27, 1993 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-7916657
ABSTRACT
The Drosophila anachronism (ana) locus controls the proliferation of neuroblasts, neuronal stem cells that give rise to the central nervous system. In ana mutants, quiescent postembryonic central brain and optic lobe neuroblasts enter S phase precociously. ana encodes a novel secreted protein of 474 amino acids that is expressed not in the affected neuroblasts, but rather in a subclass of neighboring glial cells. These studies argue for an important role for glia in negatively regulating proliferation of neuronal precursor cells, thereby controlling the timing of postembryonic neurogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas
/
Neuroglia
/
Proteínas de Drosophila
/
Drosophila
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article