Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.
Nat Genet
; 7(2): 125-9, 1994 Jun.
Article
em En
| MEDLINE
| ID: mdl-7920628
ABSTRACT
The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of Fc epsilon RI-beta, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60 unrelated nuclear families with allergic asthmatic probands, Leu181 is identified in 10 (17%), is maternally inherited in each, and shows a strong association with atopy. Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de IgE
/
Hipersensibilidade Imediata
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article