Trans-urocanic acid, a natural epidermal constituent, inhibits human natural killer cell activity in vitro.
Exp Dermatol
; 3(2): 61-5, 1994 Apr.
Article
em En
| MEDLINE
| ID: mdl-7921652
ABSTRACT
UV irradiation has been reported to influence NK cell function both in vitro and in vivo. Since urocanic acid may mediate UV-induced immune modulation we tested the effect of trans- and cis-urocanic acid (UCA) on the cytotoxic activity of human peripheral blood lymphocytes against the erythroleukemic target cell line K562 in vitro. Trans-UCA was found to be a strong inhibitor of NK cell activity whereas cis-UCA had no effect. Trans-UCA also partially inhibited cytotoxic function of IL-2-activated NK cells and reduced IL-2-induced activation of NK cells. This is the first report describing trans-UCA to be active, and cis-UCA inactive, in regulating an immune function. In the skin, a decrease in epidermal trans-urocanic acid concentration by UV radiation could produce a favorable milieu for NK cell activity, and thus counteract the impairment of antigen-specific immune surveillance, induced by increased cis-urocanic acid concentrations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Urocânico
/
Células Matadoras Naturais
/
Epiderme
Limite:
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article