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What is the pathogenetic role of antiphospholipid antibodies?
Meroni, P L; Tincani, A; Barcellini, W; Del Papa, N; Gambini, D; Piona, A; La Rosa, L; Balestrieri, G.
Afiliação
  • Meroni PL; Istituto di Medicina Interna, Malattie Infettive e Immunopatologia, University of Milan, Italy.
Clin Exp Rheumatol ; 12 Suppl 10: S43-7, 1994.
Article em En | MEDLINE | ID: mdl-7955626
The association between antiphospholipid antibodies (aPL) and arterial or venous thrombosis, fetal loss and thrombocytopenia defines the so-called "antiphospholipid syndrome" (APS). Despite serial studies in recent years, a clear pathogenetic mechanism(s) has not yet been demonstrated. Several authors have investigated the interaction between aPL and the membranes of blood cells (endothelial cells and platelets) involved in coagulation. aPL is also thought to affect the balance between the procoagulant and anticoagulant states by interacting with plasma or tissue cofactors. Finally, the strong association between aPL and experimental animal models of fetal loss supports a direct pathogenetic role for aPL in inducing a poor pregnancy outcome in APS women.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Antifosfolipídica / Anticorpos Antifosfolipídeos Limite: Animals / Female / Humans / Pregnancy Idioma: En Ano de publicação: 1994 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Antifosfolipídica / Anticorpos Antifosfolipídeos Limite: Animals / Female / Humans / Pregnancy Idioma: En Ano de publicação: 1994 Tipo de documento: Article