Metabolites of chloroquine: some observations on desethylchloroquine and N-acetyldesethylchloroquine.
J Pharm Sci
; 83(7): 1040-2, 1994 Jul.
Article
em En
| MEDLINE
| ID: mdl-7965661
ABSTRACT
The major metabolite of chloroquine, (+)-desethylchloroquine, produced by stereoselective N-dealkylation of the drug, was obtained in 81.5% enantiomeric purity by resolution of racemic desethylchloroquine using an atropisomeric resolving agent and was shown by circular dichroism to have the absolute (S)-configuration. The minor metabolite N-acetyldesethylchloroquine was prepared in both the racemic and the (S)-(+)-form.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cloroquina
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article