Alcoholism and rapid progression to AIDS after seroconversion.
Clin Infect Dis
; 19(2): 337-8, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-7986912
ABSTRACT
Rapid progression of infection with human immunodeficiency virus type 1 (HIV-1) to AIDS after seroconversion is rare; it has been associated with coinfection by cytomegalovirus or human T lymphotrophic virus type I. We describe an alcoholic patient whose condition progressed to AIDS 3 months after HIV-1 seroconversion occurred. Culture of peripheral blood mononuclear cells yielded a syncytium-inducing variant of HIV-1. T lymphocytes showed no spontaneous cytotoxic activity against HIV-infected cells, nor could such activity be demonstrated following stimulation with HIV-1 antigen in the presence of recombinant interleukin-2. We hypothesize that our patient's accelerated course was due to alcohol abuse, which may have suppressed T cell function and stimulated HIV replication.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Síndrome da Imunodeficiência Adquirida
/
HIV-1
/
Soropositividade para HIV
/
Alcoolismo
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article