Lack of evidence for a superantigen in lymphocytes from HIV-discordant monozygotic twins.
AIDS
; 8(4): 443-9, 1994 Apr.
Article
em En
| MEDLINE
| ID: mdl-8011247
ABSTRACT
OBJECTIVE:
An HIV-associated superantigen (SAg) has been hypothesized. Here we test whether an SAg is functionally detectable in peripheral blood mononuclear cells (PBMC) from monozygotic twins discordant for HIV infection. DESIGN ANDMETHODS:
The V beta selective T-cell depletion found in minor lymphocyte stimulation (Mls)-positive mice is caused by an SAg encoded by the mouse mammary tumour virus. Mls is a locus whose gene product stimulates a mixed lymphocyte reaction (MLR) in mice strains identical at the major histocompatibility complex locus. If an SAg is present in PBMC and/or sorted CD4+ cells from one HIV-infected monozygotic twin, it would stimulate PBMC from the corresponding healthy monozygotic twin in an MLR. In addition, if an SAg causes V beta-selective T-cell depletion in AIDS patients, a differential proliferation to a panel of staphylococcal enterotoxins (SE) of T lymphocytes from healthy and HIV-infected monozygotic twins should become measurable.RESULTS:
No positive MLR or significant differences in the SE-driven proliferation between the healthy and the HIV-infected twins were observed.CONCLUSIONS:
Our results suggest that PBMC from the two HIV-infected twins do not express a functionally detectable SAg.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gêmeos Monozigóticos
/
Linfócitos
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Infecções por HIV
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HIV
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Superantígenos
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Doenças em Gêmeos
Limite:
Adult
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article