Determination of the coumarin anticoagulant phenprocoumon and metabolites in human plasma, urine and breast milk by high-performance liquid chromatography after solid-phase extraction.
J Chromatogr B Biomed Appl
; 655(1): 63-71, 1994 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-8061835
ABSTRACT
The coumarin anticoagulant phenprocoumon (PH) and metabolites (6-, 7- and 4'-hydroxyphenprocoumon) were analysed in plasma and urine samples from anticoagulated patients using solid-phase extraction and high-performance liquid chromatography with reversed-phase columns and ultraviolet and fluorescence detection; a simpler handling of samples, higher selectivity, precision, accuracy and analytical recovery were obtained compared to analysis using liquid-liquid extraction. Similarly, a method for the analysis of PH in human breast milk was developed to assess the passage of anticoagulants into breast milk in anticoagulated lactating women.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Femprocumona
/
Leite Humano
/
Anticoagulantes
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article