Transfer of cryopreserved-thawed pre-embryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results.
Fertil Steril
; 62(3): 545-50, 1994 Sep.
Article
em En
| MEDLINE
| ID: mdl-8062950
ABSTRACT
OBJECTIVE:
To examine the results of 7 years of thawed ET during natural or controlled cycles using exogenous steroids.DESIGN:
Retrospective evaluation to compare implantation and pregnancy rates with two protocols for transfer of cryopreserved-thawed pre-embryos.SETTING:
Tertiary care academic center. PATIENTS From January 1987 to December 1993, 521 patients who were < 40 years of age underwent 628 thawed embryo transfers. MAIN OUTCOMEMEASURE:
Pregnancy and implantation rates per thawed embryo transfer cycle.RESULTS:
A total 1,987 pre-embryos survived the thawing process and were used in 628 thaw-transfer cycles. Transfer was performed in a natural cycle 2 days after the LH peak or on day 17 of a programmed cycle using a GnRH-agonist and hormone replacement therapy protocol; 182 pregnancies were established (182/628; 29%). Similar pregnancy rates were seen in the natural cycle (112/398; 28%) and the programmed cycle (70/230; 30%). The implantation rates were similar in the two methods of transfer cycles (11.9% versus 10.3%, natural versus programmed cycle). There were no significant differences in clinical or ongoing pregnancy rates in a natural or programmed cycle, correcting for the number of cryopreserved-thawed pre-embryos transferred. Patient's age at the time of freezing and the number of cryopreserved-thawed pre-embryos transferred are more important determinants of pregnancy than the type of cycle in which transfer occurs.CONCLUSION:
Transferring cryopreserved-thawed pre-embryos in a natural or programmed cycle yields similar pregnancy results.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gravidez
/
Criopreservação
/
Transferência Embrionária
/
Hormônios
/
Ciclo Menstrual
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article