Influence of the emulsion sign in phenytoin bioavailability.
Boll Chim Farm
; 133(4): 239-45, 1994 Apr.
Article
em En
| MEDLINE
| ID: mdl-8068235
ABSTRACT
To study the influence of the emulsion sign in phenytoin bioavailability, two emulsions (w/o and o/w) were prepared. Bioavailability studies were carried out with both emulsions in Wistar male rats. The study was of a randomized two-way cross over design. A radiotracer technique was chosen as analytical procedure, due to the small blood sample collected. 14C-phenytoin was synthesized with a high yield and suitable radiochemical purity. It is concluded, from a biopharmaceutic point of view, that the emulsion sign does not seem to affect the amount of phenytoin absorbed, as it is shown through the comparison of the areas under curve up to 24 h. An emulsion with oil as an external phase is responsible of a longer absorption, taking into account the apparent elimination constant rates.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenitoína
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article