Cytosaminomycins, new anticoccidial agents produced by Streptomyces sp. KO-8119. I. Taxonomy, production, isolation and physico-chemical and biological properties.
J Antibiot (Tokyo)
; 47(7): 774-81, 1994 Jul.
Article
em En
| MEDLINE
| ID: mdl-8071122
ABSTRACT
Streptomyces amakusaensis KO-8119, a soil isolate, was found to produce a series of new anticoccidial compounds. Four active compounds, designated as cytosaminomycins A, B, C and D, were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and preparative HPLC. Cytosaminomycins inhibited the growth of Eimeria tenella in an in vitro assay system using primary chicken embryonic cells as a host. No schizont in the cells was observed at concentrations ranging from 0.3 to 0.6 microgram/ml for cytosaminomycins A, B and C, and at 2.5 micrograms/ml for cytosaminomycin D.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Coccidiostáticos
/
Aminoglicosídeos
/
Antibacterianos
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article