Nontypeable and encapsulated Haemophilus influenzae yield different clinical courses of experimental otitis media.
Acta Otolaryngol
; 114(3): 289-94, 1994 May.
Article
em En
| MEDLINE
| ID: mdl-8073862
ABSTRACT
Middle ears of male Sprague-Dawley rats were injected with suspensions of thirteen Haemophilus influenzae strains of different sero- and biotypes and at various concentrations. Systemic and local changes were monitored by clinical observations, otomicroscopy, and analysis of bacterial samples from blood and middle ears. Two patterns of response were recognized, a nontypeable and an encapsulated pattern. The nontypeable H. influenzae middle ear infection required a high bacterial dose and was well past its peak 8 days after challenge, when the encapsulated H. influenzae otitis media was still purulent. The most severe infections were caused by H. influenzae type b strains. The overall mortality rate was zero and the animals recovered without permanent deterioration or otomicroscopically discernable changes. The results of this study show the rat to be a suitable animal model for the study of H. influenzae otitis media.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Otite Média
/
Haemophilus influenzae
/
Infecções por Haemophilus
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article