Apoptosis associated DNA fragmentation in epileptic brain damage.
Neuroreport
; 5(9): 1053-5, 1994 May 09.
Article
em En
| MEDLINE
| ID: mdl-8080958
ABSTRACT
We have examined the epileptic brain damage generated by intra-amygdaloid administration of kainic acid (KA). In the vulnerable CA3 region of the rat hippocampus, neurones developed apoptotic properties since, (i) their nuclei were positively stained with a selective in situ DNA fragmentation staining method; (ii) DNA cleavage into internucleosome-sized fragments was observed on agarose gels. Our results suggest that epileptic seizures generated in the amygdala by KA trigger apoptotic cell damage in pyramidal CA3 neurones.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
/
DNA
/
Apoptose
/
Epilepsia
/
Ácido Caínico
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article