Pineal photoreceptors rhythmically secrete melatonin.
Neurosci Lett
; 171(1-2): 109-12, 1994 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-8084468
ABSTRACT
Individual pineal cells secrete melatonin with a circadian period, reducing a vertebrate circadian system to the level of a single cell [Brain Res., 627 (1993) 141-146]. In the present study, dissociated pineal cells were identified as melatonin-secreting by a reverse hemolytic plaque assay (RHPA) and all melatonin-secreting cells were immuno-positive when analyzed for the photoreceptor protein S-antigen. The results are the first direct evidence that isolated photoreceptor cells secrete melatonin and taken together with our previous findings indicate that single pineal cells contain (1) a circadian oscillator; (2) a photoreceptive capacity; and (3) the ability to secrete melatonin rhythmically.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Fotorreceptoras
/
Glândula Pineal
/
Melatonina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article