SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins.
Oncogene
; 9(4): 1205-11, 1994 Apr.
Article
em En
| MEDLINE
| ID: mdl-8134123
ABSTRACT
Amplification of 12q13-14 occurs in a subset of human sarcomas including malignant fibrous histiocytoma and liposarcoma. This chromosomal region has previously been found to include a number of growth-related genes including the GLI proto-oncogene and the p53-associated protein, MDM2. We now report the characterization of SAS (sarcoma amplified sequence), a novel transcript found in this region. Sequence analysis demonstrates that SAS is a novel member of a transmembrane protein family (transmembrane 4 superfamily or TM4SF) thought to be involved in growth-related cellular processes. This observation adds a TM4SF protein to the cluster of genes at 12q13-14 frequently amplified in human sarcomas.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Amplificação de Genes
/
Proteínas de Membrana
/
Proteínas de Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article