Pharmacologic management of obsessive-compulsive disorder.
South Med J
; 87(3): 310-21, 1994 Mar.
Article
em En
| MEDLINE
| ID: mdl-8134850
ABSTRACT
Obsessive-compulsive disorder (OCD) is an intriguing, difficult problem characterized by anxiety-producing intrusive thoughts and performance of anxiety-reducing rituals. Current evidence suggests that OCD may be associated with dysregulation of serotonin and dopamine neurotransmission. Numerous early studies involving the serotonin-specific reuptake inhibitor clomipramine led to the formulation of this hypothesis. Positive results with clomipramine initiated further research with other serotonin-specific reuptake inhibitors, such as fluoxetine, fluvoxamine, sertraline, and serotonergic agents such as buspirone and trazodone. Findings from a number of clinical trials suggest that drugs that inhibit serotonin reuptake or affect serotonergic transmission in other ways are of clear benefit in the treatment of OCD. These drugs may be more effective for obsessive thoughts than for compulsive rituals. Effective pharmacotherapy can dramatically decrease obsessive-compulsive symptoms and improve the patient's quality of life.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clomipramina
/
Inibidores Seletivos de Recaptação de Serotonina
/
Antidepressivos
/
Transtorno Obsessivo-Compulsivo
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article