Cytogenetic triclonality in acute myeloid leukemia: a morphologic, immunologic and in situ hybridization study.
Cancer Genet Cytogenet
; 72(2): 86-91, 1994 Feb.
Article
em En
| MEDLINE
| ID: mdl-8143281
ABSTRACT
Cytogenetically unrelated clones are uncommon in hematologic malignancies. We report a case of acute myeloid leukemia, which consisted morphologically of two populations of small and large blasts demonstrating immunophenotypic heterogeneity. Cytogenetic analysis showed 3 karyotypically abnormal clones 47,XY, +14/45,XY,dic(5;17)(q11;p11),14dmin, and a near-tetraploid clone. In situ hybridization showed that the near-tetraploid clone corresponded to the large blasts, and the near-diploid clones the small blasts, therefore demonstrating a direct relationship between cell size and DNA content. The diverse morphologic, immunologic and cytogenetic heterogeneity observed in our case suggested hematopoietic oligoclonality.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Aberrações Cromossômicas
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article