Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS)
Science
; 262(5131): 240-2, 1993 Oct 08.
Article
em En
| MEDLINE
| ID: mdl-8211142
ABSTRACT
The murine acquired immunodeficiency syndrome (MAIDS) is induced by a defective murine leukemia virus and has many symptoms similar to those found in patients infected with the human immunodeficiency virus. The presence of both B cells and CD4+ T cells is critical for the development of the disease. Furthermore, a Th2 cytokine response dominates during the progression of the disease. When interleukin-4 (IL-4)-deficient mice that are defective in Th2 cytokine responses were infected, there was no lethality, and the development of the T cell abnormalities associated with MAIDS was delayed. These data suggest that IL-4 or a Th2 response is involved in the development of retrovirus-induced immunodeficiency in mice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Imunodeficiência Adquirida Murina
/
Interleucina-4
/
Linfócitos T Auxiliares-Indutores
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article