[The synthesis and bioactivities of cholinergic tropane alkaloids].
Yao Xue Xue Bao
; 28(4): 302-6, 1993.
Article
em Zh
| MEDLINE
| ID: mdl-8213175
ABSTRACT
Ten analogs of baogongteng A, the natural cholinergic tropane alkaloid isolated from Erycibe obtusifolia Benth, were designed and synthesized. The tropane skeleton was kept unchanged, while the substituting groups on N and C3 were modified. In myotic experiments in rabbits 3-paramethyl benzoyloxy-6-acetoxy nortropane(4), 3-propionyloxy-6-acetoxy nortropane(5), and 3-isobutyryloxy-6-acetoxy nortropane(6) showed cholinergic activities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parassimpatomiméticos
/
Compostos Bicíclicos com Pontes
/
Medicamentos de Ervas Chinesas
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Mióticos
Limite:
Animals
Idioma:
Zh
Ano de publicação:
1993
Tipo de documento:
Article