Familial calcification of aorta and calcific aortic valve disease associated with immunologic abnormalities.
Am Heart J
; 126(4): 904-9, 1993 Oct.
Article
em En
| MEDLINE
| ID: mdl-8213448
ABSTRACT
We report three patients of the same family with linear calcification of the ascending aorta, severe calcific mixed aortic valve disease associated with increased levels of globulins, lambda-chain gammopathy, an increased T4/T8 lymphocyte ratio, and other immunologic abnormalities. None of the patients had syphilis, atherosclerosis, abnormalities of calcium or phosphorus metabolism, lymphadenopathy, or other systemic diseases. It is postulated that these cases and some previously reported in the literature as idiopathic represent a distinct pathologic entity, familial or sporadic, in which localized vascular and valvular calcific disease is associated with an underlying immunologic disorder or autoimmune process.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças da Aorta
/
Insuficiência da Valva Aórtica
/
Estenose da Valva Aórtica
/
Calcinose
/
Cadeias Leves de Imunoglobulina
/
Hipergamaglobulinemia
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article