99mTc-bioquin-7CA, a potential new hepatobiliary scanning agent.
J Nucl Med
; 17(10): 907-10, 1976 Oct.
Article
em En
| MEDLINE
| ID: mdl-823309
ABSTRACT
The complex 99mTc-Sn-8-hydroxyquinoline-7-carboxylate (99mTc-bioquin-7CA) was investigated in animals as a potential hepatobiliary scanning agent. Following intravenous injection, the complex was found to localize in the liver rapidly and in the gallbladder in 5--15 min; after 15 min it was excreted into the biliary tract with a high degree of specificity. Urinary excretion was negligible, reducing scan interference from the kidneys. Distribution studies in mice compared well withe localization of activity observed in rabbit scans. Preparation of the complex was rapid and simple; stannous ion was used as the reducing agent.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Biliares
/
Oxiquinolina
/
Hidroxiquinolinas
/
Hepatopatias
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article