Generation of matrix-degrading proteolytic system from fibronectin by cathepsins B, G, H and L.
Biol Chem Hoppe Seyler
; 374(8): 651-6, 1993 Aug.
Article
em En
| MEDLINE
| ID: mdl-8240719
ABSTRACT
By their endoproteinase activities, cathepsins B, G, H and L can generate matrix-degrading proteolytic system from fibronectin. All four cathepsins studied cleaved fibronectin in fragments that were either proteolytically active or activated after incubation at pH 7.4 and in the presence of Ca2+. The highest enhancement of the matrix protein-degrading activity was observed after a gelatin-affinity chromatography of each digest. These results suggest that the effect of cathepsins at physiological pH in vivo may be enhanced by the activation of a matrix-degrading proteolytic system from fibronectin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeo Hidrolases
/
Catepsinas
/
Fibronectinas
/
Matriz Extracelular
Limite:
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article