Transmission from one child to another of human immunodeficiency virus type 1 with a zidovudine-resistance mutation.
N Engl J Med
; 329(25): 1835-41, 1993 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-8247034
ABSTRACT
BACKGROUND AND METHODS. We describe a child who apparently acquired human immunodeficiency virus type 1 (HIV-1) infection in the home setting. The suspected source of infection was a child with the acquired immunodeficiency syndrome who had received zidovudine and whose virus contained a mutation associated with in vitro zidovudine resistance. The children were born to different HIV-1-infected mothers, but they lived in the same home between the ages of two and five years. Child 1 was infected perinatally; Child 2 was not and was repeatedly found to be seronegative. Child 2 was examined because of acute lymphadenopathy and had seroconverted to HIV-1 positivity. HIV-1 proviral DNA was amplified from peripheral-blood mononuclear cells and subjected to sequence analysis. Sequences from Child 2 were compared with those from Child 2's mother, Child 1, and local HIV-1-infected control children.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zidovudina
/
Infecções por HIV
/
HIV-1
Limite:
Child, preschool
/
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article