[Expression of EGF-R in gastric carcinoma and precancerous lesion].
Zhonghua Zhong Liu Za Zhi
; 15(3): 192-4, 1993 May.
Article
em Zh
| MEDLINE
| ID: mdl-8261863
ABSTRACT
The expression of epidermal growth factor receptor (EGF-R) in normal gastric mucosa, gastric mucosal dysplasia, early and advanced gastric carcinoma was studied with the monoclonal antibody to EGF-R by using immunohistochemical ABC method. Normal gastric mucosa was negative for EGF-R, but a relatively high positive rate was found in dysplasia. When gastric carcinoma occurred, the positive rate decreased. The expression of EGF-R was related to the poor differentiation and strong infiltration of gastric carcinoma. The carcinoma with the expression of EGF-R was easy to metastasize to lymph nodes. The result suggests that EGF-R might play some role in the process of carcinogenesis of gastric mucosa, and be used as a useful marker for the assessment of the biological behavior of gastric carcinoma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
/
Neoplasias Gástricas
/
Adenocarcinoma
/
Biomarcadores Tumorais
/
Receptores ErbB
Limite:
Humans
Idioma:
Zh
Ano de publicação:
1993
Tipo de documento:
Article