Test and teach. Number seventy-three. Diagnosis: Alexander's disease.
Pathology
; 25(3): 254, 321, 1993 Jul.
Article
em En
| MEDLINE
| ID: mdl-8265244
ABSTRACT
Alexander's disease is a progressive degenerative neurological disorder developing in early childhood which is characterized by accumulation of Rosenthal fibres throughout the cerebral white matter. These fibres are composed of glial fibrillary acidic protein and ubiquinated alpha beta crystallin. The absence of atypia, increased cellularity, mitotic activity or necrosis in biopsy material allows differentiation from neoplasia glial processes. Clinical features suggestive of the diagnosis include progressive mental retardation with an increase in head circumference.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Crânio
/
Encefalopatias
/
Proteína Glial Fibrilar Ácida
/
Deficiência Intelectual
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Infant
/
Male
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article