Neurological and behavioral effects of a unilateral frontal cortical lesion in fetal kittens. II. Visual system tests, and proposing an "optimal developmental period" for lesion effects.

ABSTRACT

Nine fetal kittens sustained removal of the left frontal cortex during the last third of gestation (E 43-55) and were compared to animals sustaining a similar lesion postnatally (P 8-14) as well as to intact littermates. Beginning after 6 months of age, the animals' visual field and depth perception were assessed. In addition, pupil size as well as eye alignment were measured. On two visual field tests the fetal-lesioned cats showed test dependent decrements for some angles of vision. In terms of depth perception, only the prenatal-lesioned animals showed a higher binocular threshold; they also showed ocular misalignment which may have contributed to their depth perception impairment. Moreover, these animals had a larger ipsilateral pupil. The neonatal-lesioned animals were like normal cats for all tests and measurements. We conclude that, as for the tests reported in the preceding paper, the outcome for visual related behaviors of a prenatal frontal cortical lesion in the cat is also worse than that of a similar lesion sustained neonatally. Dysgenetic anatomical changes of the visual system induced indirectly by the frontal lesion are proposed as a possible explanation for these age-at-lesion differences. Based on the present work as well as on the literature, we propose the existence of an "optimal developmental period" for the best behavioral and anatomical outcome of perinatal brain lesions. We argue that this concept fits contemporary data and can better explain the different age-at-lesion effects of brain injury across animals species than the "Kennard Principle" (or "infant-lesion effect").