Phase II study of fotemustine as second-line treatment after failure of immunotherapy in metastatic renal cell carcinoma.
Cancer Chemother Pharmacol
; 32(4): 329-31, 1993.
Article
em En
| MEDLINE
| ID: mdl-8324878
ABSTRACT
Sixteen patients who after prior systemic immunotherapy had progressing disease received fotemustine (100 mg/m2) i.v. on days 1, 8, and 15 followed by a 5-week rest period. In responding or stabilized patients, maintenance therapy consisted of 100 mg/m2 fotemustine given once every 3 weeks until progression on toxicity occurred. No objective response was observed. Four patients showed stable disease (median duration 4 months; range 3-19). The main toxicities were neutropenia (WHO grade 3 and 4 27%) and thrombocytopenia (WHO grade 3 and 4 27%). Fotemustine was administered on an outpatient basis and was generally well tolerated, but in our series of patients it had no antitumour activity in metastatic renal cell carcinoma after failure of immunotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
/
Carcinoma de Células Renais
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Neoplasias Renais
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Antineoplásicos
/
Compostos de Nitrosoureia
Limite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article