Metabolic activation of aflatoxin B1 by human placental microsomes.
J Toxicol Sci
; 18(2): 129-32, 1993 May.
Article
em En
| MEDLINE
| ID: mdl-8331693
ABSTRACT
The metabolic activation of aflatoxin B1 by human placental microsomes was studied. Aflatoxin B1 showed relatively high mutagenic activity in Ames test when incubated with human placental microsomes. Addition of alpha-naphthoflavone or aminoglutethimide, known inhibitors of cytochrome P450 1A and P450 19, respectively, into the test system partially inhibited the mutagen-producing activity. It was suggested that the activation of aflatoxin B1 in human placental microsomes is mediated by at least these two forms of cytochrome P450.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Aflatoxina B1
/
Microssomos
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article