The effects of Benadryl and Hismanal on psychomotor performance and perceived performance.
Aviat Space Environ Med
; 64(8): 726-34, 1993 Aug.
Article
em En
| MEDLINE
| ID: mdl-8368986
ABSTRACT
Classic antihistamines (H1 antagonists) have sedative effects and can impair psychomotor performance. It is claimed that Hismanal (astemizole) does not possess central nervous system side effects. A three-factor, repeated measures, double-blind design was used to compare the effects of single oral doses of (1) Benadryl (diphenhydramine)-50 mg, (2) Hismanal-10 mg, and (3) placebo on a battery of 11 cognitive information-processing tasks and performance ratings in 28 healthy men. Performance decrements were seen at 1 h post-Benadryl ingestion on Following Directions (p < 0.05), at 1.5 h on Unstable Tracking (p < 0.05), and at 3 h on serial addition/subtraction (p < 0.05). No decrements in performance were found post-Hismanal. Subjects perceived their performance as poorer following Benadryl ingestion versus placebo and Hismanal for 3 h postingestion (p < 0.05). Results demonstrate performance effects post-Benadryl ingestion for 1 h longer than previously reported. Tasks which demonstrated sensitivity to antihistamines were those which required an element of sustained attention and those which required a visual-motor response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Percepção
/
Desempenho Psicomotor
/
Astemizol
/
Difenidramina
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article