Skeletal muscle mitochondrial beta-oxidation of dicarboxylates.
Biochim Biophys Acta
; 1141(1): 81-9, 1993 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-8435437
ABSTRACT
(1) The oxidation of [U-14C]hexadecanedionoyl-mono-CoA by rat skeletal muscle mitochondrial fractions is carnitine dependent and is inhibited by cyanide. (2) [U-14C]hexadecanedionoyl-mono-CoA was oxidised at a rate 8% of that of [U-14C]hexadecanoyl-CoA. (3) Oxidations were saturable and no substrate inhibition was observed. (4) We demonstrate the formation of dicarboxylyl-mono-CoA esters and the corresponding carnitine derivatives. (5) We conclude that, although skeletal muscle mitochondria are capable of the beta-oxidation of dicarboxylic acids, this is unlikely to be of great physiological significance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Palmitoil Coenzima A
/
Acil Coenzima A
/
Mitocôndrias Musculares
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article