Morphine physical dependence in the hibernator: central nervous system mechanisms underlying the development of dependence remain functional during depression induced by pentobarbital anesthesia.
Life Sci
; 52(13): 1079-86, 1993.
Article
em En
| MEDLINE
| ID: mdl-8450704
ABSTRACT
Earlier work suggested that adaptive mechanisms of the hibernating brain may also block the development of morphine physical dependence. To test an alternate view that CNS depression itself might be the major factor in the failure of dependence to develop, we compared the strength of dependence produced by morphine (two 75-mg pellets, s.c.) given for 12 hr in the presence, versus in the absence, of continuous pentobarbital anesthesia in nonhibernating ground squirrels (Citellus lateralis) and, in addition, in rats. Dependence was measured by the naloxone (5 mg/kg, s.c.) evoked abstinence syndrome in the awake state. The results demonstrated that pentobarbital-induced general anesthesia does not significantly reduce the development of morphine dependence in either species. We conclude that CNS depression alone does not account for the hibernation-related reduction in morphine physical dependence.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pentobarbital
/
Sciuridae
/
Sistema Nervoso Central
/
Transtornos Relacionados ao Uso de Substâncias
/
Hibernação
/
Morfina
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article