Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. I. Producing strain, fermentation, isolation and biological activity.
J Antibiot (Tokyo)
; 46(2): 222-8, 1993 Feb.
Article
em En
| MEDLINE
| ID: mdl-8468235
ABSTRACT
Pepticinnamins A, B, C, D, E and F, a family of farnesyl-protein transferase (FPT) inhibitors were isolated from the fermentation broth of Streptomyces sp. OH-4652. These inhibitors were purified from whole broth by extraction with chloroform, followed by silica gel column chromatography, Sephadex LH-20 chromatography and reverse phase HPLC. Among these, pepticinnamin C showed the most potent inhibition (IC50-100 nM).
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Streptomyces
/
Transferases
/
Alquil e Aril Transferases
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article